Yes. I was prescribed Zoloft, and was pretty optimistic since I personally knew someone who was greatly helped by it. After several days on a very low dose, I felt like crap. I felt like I was going more crazy than I has been at first. Then one day, within a week of starting the stuff, about the middle of the day, I heard a voice from within me distinctly say, "You really need to kill yourself and get this over with." I had never, even in my darkest hours, ever heard/ experienced anything like that before. Needless to say, I was off Zoloft the next day.